• Fatigue or low energy: Tiredness or reduced stamina that may relate to mitochondrial dysfunction or nutrient insufficiency.
• Mood and cognitive health: Low mood, anxiety, poor focus or memory changes possibly linked to neurotransmitter or amino acid metabolism.
• Chronic stress: Ongoing stress or poor stress resilience that may influence adrenal function, energy production or nutrient demand.
• Inflammation and oxidative stress: Joint discomfort, tissue irritation or signs of oxidative imbalance that may reflect antioxidant depletion.
• Digestive function: Bloating, altered bowel habits or signs of malabsorption that may be associated with dysbiosis or nutrient absorption issues.
• Cardiometabolic health: Weight gain, blood sugar imbalance or early cardiovascular changes potentially linked to fatty acid or organic acid markers.
• Nutrient status: Assessment of functional need for antioxidants, B-vitamins, amino acids and minerals that support metabolic pathways.
• Metabolic function: Exploration of altered organic acid, amino acid or fatty acid patterns in complex presentations affecting energy, cognition or weight regulation.

Overview

Metabolomix+ combines several nutritional profiles to provide a broad analysis of key organic acids, amino acids and oxidative stress markers. This integrated approach evaluates core biochemical pathways and offers a functional overview of nutrient status, energy metabolism and detoxification capacity, helping to identify potential nutritional insufficiencies or metabolic imbalances.

The test includes assessment of mitochondrial function, oxidative stress, detoxification, neurotransmitter metabolism and dysbiosis-related metabolites. Add-on options for fatty acids, urine elements and vitamin D can further expand the profile to include essential fats, minerals and nutrient co-factors.

Changes in organic acid, amino acid and fatty acid patterns have been observed in contexts such as fatigue, mood variation, metabolic dysfunction and cardiometabolic risk. Metabolomix+ offers a convenient non-invasive way to explore how nutritional status and lifestyle factors may influence these biochemical pathways and supports a personalised approach to nutritional planning.

Practical

Sample required:

Urine - FMV

Available add-ons:

• Fatty acids add-on for Metabolomix+
• Urine elements add-on for Metabolomix+
• Vitamin D add-on for Metabolomix+

Research

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2. Broquist HP, Luhby AL. Detection and isolation of formiminoglutamic acid from urine in folic acid deficiency in humans. Proc Soc Exp Biol Med. 1959;100(2):349-354.
3. Sun A-l, Ni Y-h, Li X-b, et al. Urinary methylmalonic acid as an indicator of early vitamin B12 deficiency and its role in polyneuropathy in type 2 diabetes. J Diab Res. 2014;2014.
4. Kwok T, Cheng G, Lai W, Poon P, Woo J, Pang C. Use of fasting urinary methylmalonic acid to screen for metabolic vitamin B12 deficiency in older persons. Nutrition. 2004;20(9):764-768.
5. Brown R, Thornton MJ, Price J. The effect of vitamin supplementation on the urinary excretion of tryptophan metabolites by pregnant women. J Clin Invest. 1961;40(4):617-623.
6. Lykouras L, Markianos M, Hatzimanolis J, Malliaras D, Stefanis C. Association of biogenic amine metabolites with symptomatology in delusional (psychotic) and nondelusional depressed patients. Prog Neuro-Psychopharmacol Biol Psych. 1995;19(5):877-887.
7. Frankenhaeuser M, Lundberg U, Von Wright MR, Von Wright J, Sedvall G. Urinary monoamine metabolites as indices of mental stress in healthy males and females. Pharmacol Biochem Behav. 1986;24(6):1521-1525.
8. Mitochondrial Medicine Society's Committee on D, Haas RH, Parikh S, et al. The in-depth evaluation of suspected mitochondrial disease. Mol Genet Metab. 2008;94(1):16-37.
9. Dimmock DP, Lawlor MW. Presentation and Diagnostic Evaluation of Mitochondrial Disease. Pediatr Clin North Am. 2017;64(1):161-171.
10. Wu H, Jiang K, Gu G, Wu Y, Yu S. [The relationship of occupational stress and the level of some hormone metabolites in urine]. Chin J Indust Hyg Occup Dis. 2014;32(2):83-86.
11. Jeon SW, Kim Y-K. Inflammation-induced depression: Its pathophysiology and therapeutic implications. J Neuroimmunol. 2017;313:92-98.
12. Rao TSS, Asha MR, Ramesh BN, Rao KSJ. Understanding nutrition, depression and mental illnesses. Indian J Psychiatry. 2008;50(2):77-82.
13. O'Connell BS. Select vitamins and minerals in the management of diabetes. Diabetes Spectr. 2001;14(3):133-148.
14. Harris WS. Omega-3 fatty acids and cardiovascular disease: a case for omega-3 index as a new risk factor. Pharmacol Res. 2007;55(3):217-223.
15. Spencer SJ, Korosi A, Layé S, Shukitt-Hale B, Barrientos RM. Food for thought: how nutrition impacts cognition and emotion. Sci Food. 2017;1(1):1-8.